The present document is an expert consensus. Specific recommendations regarding sildenafil (Viagra) and the cardiac patient are summarized in the following Table. Given the increasing reports of deaths in which the use of Viagra may be implicated, clinicians need to exercise caution when advising their patients with heart disease about taking this medication. Thus, there are possible problems in the use of Viagra in these patients that have not been adequately studied. Although the cardiovascular effects of sildenafil reported in available randomized, controlled clinical trials were relatively minor, heart disease patients represented only a small fraction of studied patients, and patients with heart failure, patients with myocardial infarction or stroke within 6 months, or patients with uncontrolled hypertension were not included in these studies. Viagra acts as a selective inhibitor of cyclic GMP (cGMP)–specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilatation, and enhanced penile erection. Until adequate studies are done in these subgroups of patients, sildenafil should be prescribed with caution. However, most patients were controlled with 1 antihypertensive agent, and only a small number were controlled with 3 antihypertensive agents. With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients. Other patients in whom the use of Viagra is potentially hazardous include those with active coronary ischemia those with congestive heart failure and borderline low blood volume and low blood pressure status those with complicated, multidrug, antihypertensive therapy regimens and those taking medications that may affect the metabolic clearance of Viagra. In patients with recurring angina after Viagra use, other nonnitrate antianginal agents, such as β-blockers, should be considered. In the event that nitrates are given, especially within this critical time interval, it is essential to have the capability to support the patient with fluid resuscitation and α-adrenergic agonists if needed. Thus, for patients who experience an acute cardiac ischemic event and who have taken Viagra within the past 24 hours, administration of nitrates should be avoided. Therefore, Viagra should not be prescribed to patients receiving any form of nitrate therapy.Īlthough definitive evidence is currently lacking, it is possible that a precipitous reduction in blood pressure with nitrate use may occur over the initial 24 hours after a dose of Viagra. The coadministration of nitrates and Viagra significantly increases the risk of potentially life-threatening hypotension. Organic nitrate preparations are commonly prescribed to manage the symptoms of angina pectoris. Most at risk are individuals who are concurrently taking organic nitrates. However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Reported cardiovascular side effects in the normal healthy population are typically minor and associated with vasodilatation (ie, headache, flushing, and small decreases in systolic and diastolic blood pressures). This article is written to appropriately caution and not to unduly alarm physicians in their use of sildenafil in patients with heart disease. The introduction of sildenafil has been a valuable contribution to the treatment of erectile dysfunction, which is a relatively common occurrence in patients with cardiovascular disease. The pharmaceutical preparation sildenafil citrate (Viagra) is being widely prescribed as a treatment for male erectile dysfunction, a common problem that in the United States affects between 10 and 30 million men. ![]() Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology. ![]()
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